Background:
Our study:
My job:
- Malaria has nearly been eliminated in Zanzibar (reaching historically low prevalences).
- Pregnant woman, especially during their first two pregnancies, are particularly susceptible to malaria sequestering in the placenta.
- Blood tests of peripheral parasitemia (peripheral = in the blood circulating around the whole body, parasitemia = the parasites that cause malaria) do not reveal the presence of placental parasitemia, but peripheral blood tests are the only ones that are systematically done to monitor malaria rates in Zanzibar and elsewhere.
- In areas of stable, high rates of malaria transmission (which it what Zanzibar was a few years ago), it is recommended by the WHO that all women receive a particular chemoprophylactic (chemo- = chemical, prophylactic = preventative) regimen called IPTp = Intermittent Preventive Treatment in pregnancy using a combination drug called SP = sulphadoxine-pyrimethamine. One dose of SP is given once after quickening, and then a second dose a month after the first dose; a third dose is recommended for HIV-positive mothers (of which there are relatively few in Zanzibar). However, no recommendations have been set for areas with historically high transmission rates but where those rates have been significantly reduced.
Our study:
- After pregnant women who have NOT received even one dose of SP as a part of IPTp give birth, but before the placenta is discarded by the medical staff, we will take a small blood sample from the placenta and check for parasitemia. This will help us judge the prevalence of placental parasitemia among women who do not receive IPTp, and therefore help us judge what the prevalence would be in the population if IPTp were not recommended for all pregnant women.
- We will try to use this data along with a cost-benefit analysis to inform a decision as to whether IPTp should be continued as a general prophylactic method to keep malaria rates down.
My job:
- Design the study (there was already a basic design in place; I am fiddling with details, doing sample size calculations, etc)
- Get ethical clearance
- Design data collection tools
- That kind of stuff.
And, thus far, I love my job.